Muscle density, but not size, is independently associated with cognitive health in older adults with hip fractures

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❇️ the state of our muscles may influence our brain’s health, particularly in older adults.
❇️ in individuals over 65 with hip fractures, those with cognitive impairments had lower muscle density, especially in specific hip muscles, compared to those without impairments.
❇️ This highlights the importance of maintaining strong and healthy muscles not just for physical well-being, but for our mental sharpness too.
❇️ Thus, cognitive impairment (CI) and muscle weakness are both risk factors for hip fracture in the older adults, posing a serious concern

Muscle density vs Muscle Mass:
❇️ Muscle density displayed a stronger association with cognitive performance than muscle size, especially the G.Med/Min muscle density.
❇️ Muscle density, as measured by the Hounsfield value on CT images, reflects the extent of intramuscular fat infiltration, better characterizing muscle quality as EWGSOP described.
❇️ Compared to muscle size, muscle density exhibited a stronger association with muscle strength and postural balance.
❇️ Interestingly, muscle quality, grip strength, and physical performance were also found to be linked to cognitive function.
❇️ Furthermore, recent evidence suggests that muscle strength and physical fitness are better indicators of CI than muscle mass

Adipose tissue, inflammation & myokines:
❇️ Adipose tissue located within muscle has been identified as an endocrine organ that regulates the muscular environment.
❇️ Adipokines and lipokines, which are signaling molecules derived from adipose tissue, are involved in glycometabolism and inflammation in skeletal muscle.
❇️ Therefore, disruptions in muscle metabolism could be correlated with insulin resistance and fluctuations in inflammatory factors.
❇️ exercise-induced myokines have been shown to have protective effects against CI and may increase levels of brain-derived neurotrophic factors.

Gluteus medius & minimus & impairments associated with aging:
❇️ The G.Med/Min muscle, the dominant abductor for the hip, plays a crucial role in maintaining balance during standing and walking.
❇️ In contrast to the G.Max muscle, which is mostly quiescent with low levels of activity, G.Med/Min muscle takes the primary responsibility for daily activities in the older adults.
❇️ Previous prospective cohort studies have identified G.Med/Min muscle density as an independent risk factor for both the first and second hip fractures


Muscle density, but not size, is independently associated with cognitive health in older adults with hip fractures

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Posted to FB on 2024-04-29 17:37:56

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