❇️ the state of our muscles may influence our brain’s health, particularly in older adults.
❇️ in individuals over 65 with hip fractures, those with cognitive impairments had lower muscle density, especially in specific hip muscles, compared to those without impairments.
❇️ This highlights the importance of maintaining strong and healthy muscles not just for physical well-being, but for our mental sharpness too.
❇️ Thus, cognitive impairment (CI) and muscle weakness are both risk factors for hip fracture in the older adults, posing a serious concern
Muscle density vs Muscle Mass:
❇️ Muscle density displayed a stronger association with cognitive performance than muscle size, especially the G.Med/Min muscle density.
❇️ Muscle density, as measured by the Hounsfield value on CT images, reflects the extent of intramuscular fat infiltration, better characterizing muscle quality as EWGSOP described.
❇️ Compared to muscle size, muscle density exhibited a stronger association with muscle strength and postural balance.
❇️ Interestingly, muscle quality, grip strength, and physical performance were also found to be linked to cognitive function.
❇️ Furthermore, recent evidence suggests that muscle strength and physical fitness are better indicators of CI than muscle mass
Adipose tissue, inflammation & myokines:
❇️ Adipose tissue located within muscle has been identified as an endocrine organ that regulates the muscular environment.
❇️ Adipokines and lipokines, which are signaling molecules derived from adipose tissue, are involved in glycometabolism and inflammation in skeletal muscle.
❇️ Therefore, disruptions in muscle metabolism could be correlated with insulin resistance and fluctuations in inflammatory factors.
❇️ exercise-induced myokines have been shown to have protective effects against CI and may increase levels of brain-derived neurotrophic factors.
Gluteus medius & minimus & impairments associated with aging:
❇️ The G.Med/Min muscle, the dominant abductor for the hip, plays a crucial role in maintaining balance during standing and walking.
❇️ In contrast to the G.Max muscle, which is mostly quiescent with low levels of activity, G.Med/Min muscle takes the primary responsibility for daily activities in the older adults.
❇️ Previous prospective cohort studies have identified G.Med/Min muscle density as an independent risk factor for both the first and second hip fractures
https://academic.oup.com/jbmrplus/article/doi/10.1093/jbmrpl/ziae047/7639166
#Healthy_Aging
#Hip_and_Groin
Posted to FB on 2024-04-29 17:37:56