Vitamin D update
❇️ Measurement of 25(OH)D has been recommended in patients at risk for deficiency.
– for example, in older adults with decreased endogenous vitamin D production and prone to develop osteoporosis, in patients with parathyroid disorders and liver disease, and in patients with obesity (BMI > 40)
❇️ The most important risk factors in the general population, as identified by recent studies, include low ambient UV radiation & low vitamin D intake
❇️ Vitamin D deficiency reduces intestinal calcium absorption leading to secondary hyperparathyroidism, bone loss, and increased risk of fractures in older adults.
– Meta-analyses of clinical trials show that vitamin D and calcium, together, decrease hip and other fractures in nursing home residents
– recent mega trials on extraskeletal effects of vitamin D suggest a link between vitamin D status and immune system and development of type 2 diabetes mellitus.
– Cardiovascular events and mortality may be positively affected as well
❇️ Daily vitamin D regimens seem to be the most efficient and beneficial strategy to improve vitamin D status
– Oral cholecalciferol (vitamin D3) remains the preferred form of vitamin D for supplementation
– The recommended dietary allowance for vitamin D by the National Academy of Medicine is set at 400 to 800 IU per day, and the tolerable upper intake level at 4000 IU per day; however, the “optimal” dose of vitamin D varies by the desired outcome, and other authors suggest that the upper limit of safety may be lower than 4000 IU per day.
– Protection was mainly associated with administering daily doses of 400 to 1000 IU for up to 12 months
https://academic.oup.com/edrv/advance-article/doi/10.1210/endrev/bnae009/7659127
#diet_and_inflammation
Consensus Statement on Vitamin D Status Assessment and Supplementation: Whys, Whens, and Hows
Posted to FB on 2024-04-29 22:34:10